About Lab Research

The mission of the Ritchie Lab is to improve our understanding of the underlying genetic architecture of common diseases such as cancer, diabetes, cardiovascular disease, and pharmacogenomic traits among others. The approaches we explore will involve the development and application of new statistical and computational methods with a focus on the detection of gene-gene interactions, gene-environment interactions, and network and/or pathway effects associated with human disease.  Systems Genomics approaches, which involve the integration of multiple types of ‘omics data, is also a driving focus of the laboratory.  These meta-dimensional approaches hold the promise of providing a more comprehensive view of genetic and genomic information. 

All of these tools and methodologies that the Ritchie Lab develops focus on Big Data applications and emphasize improvements in visual analytics as we embrace the new horizons of genomic information.

Latest Software Releases

  • BioBin 2.2.0:  The latest update for BioBin is now available.  New in this version:
    • Ability to bin with multiple phenotypes, in parallel
    • Run tests directly in BioBin, including:
      • logistic / linear regression
      • Wilcoxon rank sum test
      • SKAT
    • Improved VCF handling and many performance enhancements
    • Improved output and reporting of unlifted variants
  • PLATO 2.0.0:  The latest update for PLATO is now available.  This version is a complete rewite of PLATO, which provides the following key benefits:
    • Advanced model generation for regression models
    • Added support for more input formats, including VCF and Beagle
    • Enhanced parallelization options, including MPI

Recent Publications

  • Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols C. B. Moore, A. Verma, S. Pendergrass, S. S. Verma, D. H. Johnson, E. S. Daar, R. M. Gulick, R. Haubrich, G. K. Robbins, M. D. Ritchie, D. W. Haas, http://ofid.oxfordjournals.org/cgi/doi/10.1093/ofid/ofu113, 2, 1, ofu113-ofu113, Open Forum Infectious Diseases, 2328-8957, 2015-01-08, 10.1093/ofid/ofu113, 2015-01-19 16:18:51, CrossRef, en,
  • Design and Anticipated Outcomes of the eMERGE-PGx Project: A Multicenter Pilot for Preemptive Pharmacogenomics in Electronic Health Record Systems L J Rasmussen-Torvik, S C Stallings, A S Gordon, B Almoguera, M A Basford, S J Bielinski, A Brautbar, M H Brilliant, D S Carrell, J J Connolly, D R Crosslin, K F Doheny, C J Gallego, O Gottesman, D S Kim, K A Leppig, R Li, S Lin, S Manzi, A R Mejia, J A Pacheco, V Pan, J Pathak, C L Perry, J F Peterson, C A Prows, J Ralston, L V Rasmussen, M D Ritchie, S Sadhasivam, S A Scott, M Smith, A Vega, A A Vinks, S Volpi, W A Wolf, E Bottinger, R L Chisholm, C G Chute, J L Haines, J B Harley, B Keating, I A Holm, I J Kullo, G P Jarvik, E B Larson, T Manolio, C A McCarty, D A Nickerson, S E Scherer, M S Williams, D M Roden, J C Denny, http://www.nature.com/doifinder/10.1038/clpt.2014.137, 96, 4, 482-489, Clinical Pharmacology & Therapeutics, 0009-9236, 1532-6535, 10/2014, 10.1038/clpt.2014.137, 2015-01-19 16:11:03, CrossRef, Design and Anticipated Outcomes of the eMERGE-PGx Project,
  • Genetic variation in the HLA region is associated with susceptibility to herpes zoster D R Crosslin, D S Carrell, A Burt, D S Kim, J G Underwood, D S Hanna, B A Comstock, E Baldwin, M de Andrade, I J Kullo, G Tromp, H Kuivaniemi, K M Borthwick, C A McCarty, P L Peissig, K F Doheny, E Pugh, A Kho, J Pacheco, M G Hayes, M D Ritchie, S S Verma, G Armstrong, S Stallings, J C Denny, R J Carroll, D C Crawford, P K Crane, S Mukherjee, E Bottinger, R Li, B Keating, D B Mirel, C S Carlson, J B Harley, E B Larson, G P Jarvik, http://www.nature.com/doifinder/10.1038/gene.2014.51, Genes and Immunity, 1466-4879, 1476-5470, 2014-10-09, 10.1038/gene.2014.51, 2015-01-19 16:02:49, CrossRef,