Invited speakers:

Trudy F. C. Mackay, PhD, FRS
William Neal Reynolds and Distinguished University Professor of Genetics
Director, Program in Genetics
Associate Director, Comparative Medicine Institute
Department of Biological Sciences
North Carolina State University

David Buchner, PhD
Assistant Professor of Genetics and Genome Science
Case Western Reserve University

Yong Chen, PhD
Assistant Professor of Biostatistics
University of Pennsylvania

Daniel Himmelstein, PhD
Postdoctoral Fellow,
Department of Systems Pharmacology and
Translational Therapeutics
University of Pennsylvania

Wen Huang, PhD
Assistant Professor of Animal Science
Michigan State University

Keynote speakers:

	David Buchner, PhD Assistant Professor Department of Genetics School of Medicine Case Western Reserve University
	Brett McKinney, PhD Associate Professor of Computer Science College of Engineering & Natural Sciences Tandy School of Computer Science The University of Tulsa
	Chad Myers, PhD Associate Professor Department of Electrical and Computer Engineering University of Minnesota
	William Bush, PhD Associate Professor Department of Population and Quantitative Health Sciences Case Western Reserve University
	Scott. M. Williams, PhD Professor Department of Population and Quantitative Health Sciences Case Western Reserve University
	Robert Heckendorn, PhD Associate Professor Computer Science Department University of Idaho

Keynote speakers:

	Xinghua (Mindy) Shi, Ph.D. Associate Professor Department of Computer and Information Sciences College of Science and Technology Temple University
	Ben Lehner Group Leader Lehner Lab Systems Biology program Centre for Genomic Regulation
	Chad Myers, PhD Associate Professor Department of Electrical and Computer Engineering University of Minnesota
	Ryan Urbanowicz Assistant Professor of Informatics Department of Biostatistics Epidemiology and Informatics Perelman School of Medicine University of Pennsylvania
	John Holmes Professor of Medical Informatics in Epidemiology Department of Epidemiology and Informatics Perelman School of Medicine University of Pennsylvania

EDGE 2018 Agenda:

   ** last updated 1/3/2018**

 *TENTATIVE*

Wednesday, February 7, 2018

  Arrivals

Thursday, February 8, 2018

Friday, February 8, 2018

Saturday, February 10, 2018

  Departures

EDGE 2019 Agenda:

   ** last updated 9/11/2018**

*TENTATIVE*

Wednesday, February 6, 2019

  Arrivals

Thursday, February 7, 2019

Friday, February 8, 2019

Saturday, February 9, 2019

  Departures

EDGE 2020 Agenda:

Details coming soon

Marriott Key West Beachside Hotel
3841N. Roosevelt Blvd, Key West, FL(305) 296-8100

http://www.beachsidekeywest.com/index.php

Local Airport:

1. Key West International Airport is two miles east of Key West, in Monroe County, Florida. 
3. Address: 3491 S Roosevelt Blvd, Key West, FL 33040
4. Airport Code: EYW

Marriott Key West Beachside Hotel
3841N. Roosevelt Blvd, Key West, FL(305) 296-8100

http://www.beachsidekeywest.com/index.php

Local Airport:

1. Key West International Airport is two miles east of Key West, in Monroe County, Florida. 
3. Address: 3491 S Roosevelt Blvd, Key West, FL 33040
4. Airport Code: EYW

Marriott Key West Beachside Hotel
3841N. Roosevelt Blvd, Key West, FL(305) 296-8100

http://www.beachsidekeywest.com/index.php

Local Airport:

1. Key West International Airport is two miles east of Key West, in Monroe County, Florida. 
3. Address: 3491 S Roosevelt Blvd, Key West, FL 33040
4. Airport Code: EYW

6th Annual Epistasis Discovery in Genetics and Epidemiology (EDGE) Conference

7th Annual Epistasis Discovery in Genetics and Epidemiology (EDGE) Conference

8th Annual Epistasis Discovery in Genetics and Epidemiology (EDGE) Conference

Accommodations:

We have a small hotel block reserved at the conference hotel. Rooms will start at $149/night and are available for you to reserve until Friday, September 15, 2017.

Click here to reserve a room at the The Renaissance Long Beach

Other nearby hotels:

Local Airports:

Long Beach Airport (LGB) is a city-owned public airport three miles northeast of downtown Long Beach, in Los Angeles County, California. 
Distance to Conference Hotel: 20 minutes or 7 miles

Los Angeles International Airport (LAX) is the largest and busiest airport in the Greater Los Angeles Area and the state of California, as well as one of the largest international airports in the United States.
Distance to Conference Hotel: 30 minutes or 23 miles

John Wayne Airport (SNA) is an international airport in Orange County, California
Distance to Conference Hotel: 38 minutes or 30 miles

Conference Venue:

Renaissance Long Beach Hotel
111 East Ocean Boulevard
Long Beach, California 90802 USA

Let inspiration find you at Renaissance Long Beach Hotel. The artistic, urban Long Beach community resonates in our daily rituals and homegrown design, while the prospect of discovery lies around every corner. The Long Beach hotel’s Navigators can be your guide to the unexpected pleasures of the downtown scene — art, culture, shopping, nightlife, or whatever stirs your soul. Open your senses and experience it all in our eclectic lobby including ocean-to-fork dining at SIP Bar & Lounge and incredible local musical talent. Unwind with a refreshing swim or craft cocktail on our third-floor deck, 111 Pool + Lounge, and enjoy killer views of the Pacific Ocean and the legendary Queen Mary from our Long Beach hotel. Come meet with success, celebrate in style and amplify your senses. Our hotel in Long Beach, CA offers an inspired experience for the modern traveler.

 Poster abstract submission deadline has been extended to September 15, 2017

Call for Posters

• The organizers of TBC 2017 invite all interested participants and conference attendees to consider presenting a poster.
• When preparing accepted posters, please note that your poster should not exceed the following dimensions: 27" (68.58 cm) wide x 34" (86.36 cm) high.  This is a portrait/vertical format.
• The Proceedings of TBC 2017 will publish abstracts.

Abstract Submission   

• Online Submission System: https://easychair.org/conferences/?conf=tbc2017
  If you do not have an EasyChair account, please create an account here.
• The abstracts must be submitted in PDF format. At least one of the authors need to register by the Registration date.
• Abstract submission due on August 31, 2017  Extended to September 15, 2017
• Abstracts are limited to 250 words or less. The first page should give keywords, authors' postal and electronic mailing addresses. Abstracts must not have been previously submitted to other conferences or meetings.
• Abstracts are to be named: Abstract_LastName_FirstName_AbbreviatedTitle or keywords.PDF

Topics

• Precision Medicine
• NGS for Personal Genomics, Cancer Genomics and Metagenomics
• Rare and Common Variants of Human Genome
• Epigenomics, non-coding RNAs, and DNA methylation analysis
• Genome-Phenome-Envirome Associations
• Microarray analysis and functional genomics for disease
• Biomarkers, Drug Discovery and Pharmacogenomics
• Biomedical Text/Data Mining and Visualization
• Network Biology/Medicine and Pathway/Regulation Analysis
• Biomedical Intelligence, Clinical Informatics, and Health Record
• Semantic Biology/Medicine and Biomedical Ontologies

Paper/Abstract Submissions are now CLOSED.

Call for Papers

• The Proceedings of TBC 2017 will publish abstracts only without publishing the full-length manuscripts to protect from "prior publication".
• Selected papers will be invited to a special article of JAMIA.
• All accepted papers of TBC 2017 will be recommended to be published as journal papers by Journal of the American Medical Informatics Association (JAMIA), Journal of Biomedical Informatics (JBI), BMC Medical Genomics, BMC Medical Informatics and Decision Making, BioData Mining, Healthcare Informatics Research, and Genomics & Informatics.

     * TBC does not publish papers on the conference day, but has 3-month revision process.

Paper Submission    

• Online Submission System:  https://easychair.org/conferences/?conf=tbc2017 
     If you do not have an EasyChair account, please create an account here.
• The manuscripts must be submitted in PDF format.
•  At least one of the authors need to register by the Registration date.
• Paper submission due on May 31, 2017 June 16, 2017
  
• Full papers are limited to 12 pages, including title, abstract (250 words or less), figures, tables, text, and bibliography. The first page should give keywords, authors' postal and electronic mailing addresses. Papers must not have been previously published and must not be currently under consideration for publication elsewhere
• Papers are to be named: Paper_LastName_FirstName_AbbreviatedTitle or keywords.PDF
• Suggested Template available for download here

Call for Abstracts (Platform or Poster Presentations) 

• The Proceedings of TBC 2017 will publish abstracts.
• Selected abstracts will be invited to platform presentations at TBC. Other accepted abstracts will be invited to poster presentations.
• When preparing accepted posters, please note that your poster should not exceed the following dimensions: 27" (68.58 cm) wide x 34" (86.36 cm) high.  This is a portrait/vertical format.

Abstract Submission    

• Online Submission System:  https://easychair.org/conferences/?conf=tbc2017
      If you do not have an EasyChair account, please create an account here.
• The abstracts must be submitted in PDF format. At least one of the authors need to register by the Registration date.
• Abstract submission due on May 31, 2017   June 16, 2017
• Abstracts are limited to 250 words or less. The first page should give keywords, authors' postal and electronic mailing addresses. Abstracts must not have been previously submitted to other conferences or meetings.
• Abstracts are to be named: Abstract_LastName_FirstName_AbbreviatedTitle or keywords.PDF

Topics 

• Precision Medicine
• NGS for Personal Genomics, Cancer Genomics and Metagenomics
• Rare and Common Variants of Human Genome
• Epigenomics, non-coding RNAs, and DNA methylation analysis
• Genome-Phenome-Envirome Associations
• Microarray analysis and functional genomics for disease
• Biomarkers, Drug Discovery and Pharmacogenomics
• Biomedical Text/Data Mining and Visualization
• Network Biology/Medicine and Pathway/Regulation Analysis
• Biomedical Intelligence, Clinical Informatics, and Health Record
• Semantic Biology/Medicine and Biomedical Ontologies

Proceedings and Publications

	JAMIA (Journal of American Medical Informatics Association) is AMIA's premier peer-reviewed journal for biomedical and health informatics. Covering the full spectrum of activities in the field, JAMIA includes informatics articles in the areas of clinical care, clinical research, translational science, implementation science, imaging, education, consumer health, public health, and policy. JAMIA's articles describe innovative informatics research and systems that help to advance biomedical science and to promote health. Case reports, perspectives and reviews also help readers stay connected with the most important informatics developments in implementation, policy and education. Impact factor: 3.428 (1st in the Medical Informatics category)
	The Journal of Biomedical Informatics has been designed to reflect a commitment to high-quality original research papers, reviews, and commentaries in the area of biomedical informatics. Although we publish articles motivated by applications in the biomedical sciences (for example, clinical medicine, health care, population health, imaging, and translational bioinformatics), the journal emphasizes reports of new methodologies and techniques that have general applicability and that form the basis for the evolving science of biomedical informatics. Impact factor: 2.447
	BMC Medical Genomics is an open access journal publishing original peer-reviewed research articles in all aspects of functional genomics, genome structure, genome-scale population genetics, epigenomics, proteomics, systems analysis, and pharmacogenomics in relation to human health and disease. Impact factor: 2.726
	BMC Medical Informatics and Decision Making is an open access journal publishing original peer-reviewed research articles in relation to the design, development, implementation, use, and evaluation of health information technologies and decision-making within the healthcare setting. Impact factor: 2.042
	BioData Mining is an open access, peer reviewed, online journal encompassing research on all aspects of data mining applied to high-dimensional biological and biomedical data, focusing on computational aspects of knowledge discovery from large-scale genetic, transcriptomic, genomic, proteomic, and metabolomic data. Impact factor: 1.64
	Healthcare Informatics Research is the official journal of the Korean Society of Medical Informatics (KOSMI). The Journal provides a national and international medium for dissemination of original results and interpretative reviews concerning the field of healthcare informatics. The scope of the journal covers information systems, computer-aided decision support systems, health information infrastructure, biomedical engineering and Bioinformatics research.
	Genomics & Informatics is the official journal of the Korean Genome Organization (KOGO). It is published four times a year in a printed version and on-line. Genomics & Informatics welcomes high-quality research papers presenting novel data on the topics of gene discovery, comparative genome analyses, molecular and human evolution, informatics, genome structure and function, technological innovations and applications, statistical and mathematical methods, cutting-edge genetic and physical mapping and DNA sequencing, and other reports that present data where sequence information is used to address biological concerns.

Learning Objectives:

Translational Bioinformatics Conference (TBC) will aim to highlight the multi-disciplinary nature research field and provide an opportunity to bring together and exchange ideas between translational bioinformatics researchers. TBC puts its initial emphasis on promoting translational bioinformatics research activities initiated in Asia-Pacific region such that the first annual will be held in Seoul, Korea. Translational bioinformatics is a rapidly emerging field of biomedical data sciences and informatics technologies that efficiently translate basic molecular, genetic, cellular, and clinical data into clinical products or health implications. Translational bioinformaticians with a mix of computer scientists, engineers, epidemiologists, physicists, statisticians, physicians and biologists come together to create the unique intellectual environment of our meeting.

Learning Objectives

• Major topic areas of this year are focused on infra-technological innovations from bench to bedside, with a particular emphasis on clinical implications
• To present and exchange the latest progresses in translational bioinformatics.
• To identify the current challenges, to find research and funding opportunities, and develop future perspectives.
• To demonstrate how genomic data-driven informatics approaches can facilitate clinical research, genomic medicine, and healthcare
• To facilitate trans-disciplinary interactions among computational biology, genomics, bio-data sciences, translational medicine, and healthcare.
• To provide educational opportunities for the rapidly growing new comers.
• To develop and deploy platform for resource and problem sharing among nation-wide biomedical informatics initiatives.

Registration Information: 

*All listed fees are in US Dollars*

 Registration will close at Midnight Eastern Time on August 31, 2017.

CANCELLATION POLICY:

• Before August 1, 2017 - You may cancel your reservation for the cost of your purchased ticket, minus $50 for the processing fee.
• On or after August 1,2017 - No refunds are able to be issued. We ask that you do please still cancel so that we have appropriate counts.
• Unfortunately we are unable to transfer your ticket/registration to another individual.

Translational Bioinformatics Conference 2017

Translational Bioinformatics in Precision Medicine

 Updated: Wednesday, September 20, 2017

Agenda (pdf)

(P): Paper talk, (A): Abstract talk

Friday – September 29^th

7:00 am - 8:00 am – Breakfast and Registration

8:00 am - 8:15 am – Welcome and Introductions – Dr. Dokyoon Kim & Dr. Marylyn Ritchie

8:15 am - 9:00 am – Keynote: Dr. David Ledbetter, Precision Health at Geisinger: Longitudinal electronic health data and exome sequence on 250K participants

9:00 am - 9:45 am – Keynote: Dr. Jessie Tenenbaum, Translational Bioinformatics: Past, Present, and Future

9:45am - 10:15 am - Break

Precision medicine pipelines and applications

10:15 am-10:35 am – (P) Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records (Nicole Restrepo)

10:35 am- 10:50 am – (A) Identification of disease associations with rare Loss of Function variants from 50,000 exomes in Geisinger Health System (Anurag Verma)

10:50 am - 11:05 am - (A) iDEG: A single-subject method utilizing two-paired transcriptomes of an individual to compute differentially expressed genes (Qike Li)

11:05am - 11:25 am - (P) Rare variants in the Splicing Regulatory Elements of EXOC3L4 are associated with brain glucose metabolism in Alzheimer’s disease (Jason Miller) 

11:25 am - 11:40 am – (A) A genome-by-environment interaction classifier for precision medicine: personal transcriptome response to rhinovirus identifies children prone to asthma exacerbations (Yves Lussier)

11:40 am - 12:00 pm - (P) Frequency and phenotype consequence of APOC3 rare variants in patients with very low triglyceride levels (Dana Crawford)

12:00 pm-1:00 pm – Lunch

1:00 pm-1:45 pm – Keynote: Dr. Nicholas Tatonetti, Observational data for biomedical discovery

Pharma Informatics using the EHR

1:45 pm-2:00 pm – (A) Depression diagnosis and antidepressant treatment associated with contemporary prescriptions of narcotics and benzodiazepines with worse outcomes (Wendy Marie Ingram)

2:00 pm-2:20 pm – (P) Pharmacological Risk Factors Associated with Hospital Readmission Rates in a Psychiatric Cohort Identified using Prescriptome Data Mining (Shameer Khader)

2:20 pm-2:40 pm – (P) City-wide Analysis of Drug-Drug-Interactions (Luis Rocha)

2:40 pm-3:00 pm – Break

3:00 pm-3:45 pm –  Keynote: Dr. Ju Han Kim, Precision dinner: a personal interpretation of pharmaco and metabolic genomes

Flash Poster Talks

5:00 pm-6:30 pm – Poster Session

6:30 pm – Dismissal – Dinner on your own

Saturday – September 30^th

7:00 am - 8:00 am – Breakfast

8:00 am-8:45 am – Keynote: Dr. Dana Crawford, Diversity in precision medicine research: an example in Cleveland

Medical informatics and text mining in electronic health records

8:45 am-9:00 am – (A) Extracting metadata from large biomedical data repositories and mapping to the bioCADDIE metadata specification DATS (Data Tagging Suite) (Nansu Zong)

9:00 am-9:15 am – (A) Latent-based imputation of laboratory measures from Electronic Health Records (V. Abedi)

9:15 am-9:35 am – (P) Comparison of MetaMap and cTAKES for entity extration in clinical notes: Some remarks about aggregation and semantic types (Ruth Reategui)

9:35 am-9:55 am – (P) Text Mining MEDLINE for Rare Disease Gene Prioritization (Aditya Rao)

9:55 am-10:15 am – Break

Sequencing analysis pipelines for efficient computing

10:15 am-10:30 am–(A) More Complete Variant Discovery in Large Exome Sequencing Projects by Optimization of Analytical Pipelines (Shulan Tian)

10:30 am-10:45 am–(A) Parallel distributed PCR duplication marking algorithm integrated with genome sequence alignment by using streaming technology (Junehawk Lee)

Across the transcriptome – methods and applications

10:45 am-11:00 am– (A) Power Analysis of summary based methods for identifying expression-trait associations (Yogasudha Veturi)

11:00 am-11:20 am – (P) A novel joint analysis framework improves identification of differentially expressed genes in cross disease transcriptomic analysis (Wenyi Qin)

11:20 am-11:40 am – (P) How does normalization matter in RNA-seq disease diagnosis? (Henry Han)

11:40 am-12:00 pm– (P) Indel sensitive and comprehensive variant/mutation detection from RNA sequencing data for precision medicine (Sun Zhifu)

12:00 pm-1:00 pm – Lunch

1:00 pm-1:45 pm – Keynote: Dr. Jason Moore, Artificial intelligence for everyone

Machine learning technologies for bioinformatics

1:45 pm-2:05 pm – (P) Deep learning predicts breast cancer estrogen receptor status from metabolomics data (Fadhl Alakwaa)

2:05 pm-2:25 pm – (P) Clinical Opinion Generation from General Blood Test Results Using Binary Relevance Neural Network with Opinion Grouping (Youjin Kim)

2:25 pm-2:45 pm – (P) Min-Redundancy and Max-Relevance Multi-view Feature Selection for Predicting Ovarian Cancer Survival using Multi-omics Data (Yasser El-Manzalawy)

2:45 pm-3:00 pm – Break

3:00 pm-3:45 pm – Keynote: Dr. Ida Sim, Personal Mobile Technologies for Precision Medicine

Applications of network and pathway analysis to understand disease

3:45 pm-4:05 pm– (P) Pathway Networks Generated from Human Disease Phenome (Ann Cirincione)

4:05 pm-4:25 pm– (P) Integrative Pathway based Survival Prediction utilizing Interaction between Gene Expression and DNA Methylation in Breast Cancer (So Yeon Kim)

4:25 pm-4:40 pm–(A) Survival analysis identifies germline variants associated with overall survival among an endometrial cancer cohort (Jason Miller)

4:40 pm-5:25 pm – Keynote: Dr. Atul Butte, Translating Trillions of Points of Data into Therapies, Diagnostics, and New Insights into Disease

5:25 pm-5:45 pm – Closing Remarks/Best Paper & Abstract Award

5:45 pm – Dismissal

6:00 pm – Banquet

Sunday – October 1^st

10:00 am – Closing remarks and TBC 2017 Concludes!

 Keynote Speakers:

	Atul Butte, M.D., Ph.D. Professor, School of Medicine University of California, San Francisco
	Dana Crawford, Ph.D. Assistant Director for Research Applications Asso­ciate Pro­fes­sor of Epi­demi­ol­ogy and Bio­sta­tis­tics Insti­tute for Com­pu­ta­tional Biol­ogy Case Western Reserve University
	Ju Han Kim, M.D., Ph.D. Professor and Chair, Div. of Biomedical Informatics  Director, Systems Biomedical Informatics Research Center Seoul National University College of Medicine
	David H. Ledbetter, PhD Executive Vice President & Chief Scientific Officer Geisinger Health System
	Jason Moore, Ph.D. Edward Rose, M.D. and Elizabeth Kirk Rose, M.D. Professor Biostatistics and Epidemiology Perelman School of Medicine University of Pennsylvania
	Ida Sim, M.D., Ph.D. Professor, School of Medicine University of California, San Francisco
	Nicholas P Tatonetti, PhD Herbert Irving Assistant Professor of Biomedical Informatics Director of Clinical Informatics Herbert Irving Comprehensive Cancer Center Columbia University Presbyterian Hospital
	Jessie Tenenbaum, Ph.D. Associate Direct, Bioinformatics Duke Clinical & Translational Science Institute

IMPORTANT DATES

PAPER/ABSTRACT SUBMISSION DEADLINE - May 31, 2017 Friday, June 16, 2017

Due to numerous requests we have extended the submission deadline to Friday June 16th.  This is the only extension. June 16th is the final deadline.

Paper/Abstract acceptance notices sent - June 30, 2017 July 7, 2017  

Monday July 10th

Accepted Paper revisions due by August 6th 

Organizing Committee Members   Ju Han Kim, M.D., Ph.D. (Korea) Professor and Chair, Div. of Biomedical Informatics Director, Systems Biomedical Informatics Research Center Seoul National University College of Medicine   Atul Butte, M.D., Ph.D. (U.S.A.) Director of the Institute of Computational Health Sciences (ICHS)  University of California, San Francisco   Luonan Chen, Ph.D. (China) Key Laboratory of Systems Biology,  Shanghai Institute for Biological Sciences, China     Eleazar Eskin (U.S.A.) Professor, Computer Science, Human Genetics University of California, Los Angeles   Indira Ghosh, Ph.D. (India) Dean and Professor, School of Informatics Technology,  Jawaharlal Nehru University, New Delhi, India   Maricel G. Kann, Ph.D. (U.S.A.) University of Maryland Baltimore County    Yves A. Lussier, M.D. (U.S.A.) Prof. of Medicine, Associate Vice President of Health Sciences  University of Arizona Attended Columbia University   Lucila Ohno-Machado, M.D., Ph.D. (U.S.A.) Founding Chief, Division of Biomedical Informatics, UC San Diego Director, Biomedical Research Informatics for Global Health Program   Marylyn D. Ritchie, Ph.D. (U.S.A.) Director, Biomedical and Translational Informatics  Geisinger Health System   Tomohiro Sawa, M.D., Ph.D. (Japan)  Chief Information Officer, Headquarters, Teikyo University  Dept. of Anesthesiology, Teikyo University     Wei Wang, Ph.D. (U.S.A.)  Professor, Department of Computer Science University of California, Los Angeles

Scientific Program Committee Members:

Moore Lab and Ritchie Lab Reunion

Saturday, February 11, 2017

Key West, Florida

Venue:

Marriott Key West Beachside Hotel
3841N. Roosevelt Blvd, Key West, FL(305) 296-8100

http://www.beachsidekeywest.com/index.php

Local Airport:

1. Key West International Airport is two miles east of Key West, in Monroe County, Florida. 
3. Address: 3491 S Roosevelt Blvd, Key West, FL 33040
4. Airport Code: EYW

..

Local Favorite Restaurants:

• Tavern and Town – Key West Marriott Beachside Resort –Key West’s premiere restaurant, delicious, imaginative dishes, perfect steaks and seafood.  Tapas specials on Tuesdays and Thursdays.
• Ambrosia Japanese Restaurant –1401 Simonton St. Outstanding sushi and innovative dishes served in their new home in the brand new Santa Maria Suites.  Lunch and Dinner daily.
• Mangia Mangia – 900 Southard – Mouthwatering pasta made fresh every day.  Nestled in an old town neighborhood.
• Michael’s – 532 Margaret –  famous for it’s steaks, but everything on the menu is wonderful.  The locals favorite steak house.
• Square One – 1075 Duval in Duval Square – Fine Dining Elegant American
• Alfonso  –700 Front St. – Beautiful harbor view, great steaks and seafood,Maine lobster.
• La Trattoria/Virgilio’s  524 Duval– Northern Italian, another local favorite with a great nightclub, Virgilio’s Martini Bar – that has music, dancing.
• Antonia’s 615 Duval St – Southern Italian Excellent homemade pasta and fine wines an excellent choice.
• El Meson De Pepe’s  410 Wall Street- Real Cuban- Conch Cuisine with Latin Music Nightly located just offMallory Square
• Grand Café 314 Duval St American Cuisine with Global Influences Fresh seafood and Steak
• Commodores white table cloths fine dinning excellent, one second floor on boardwalk
• Nine One Five 915 Duval St Tapas style dinning
• CASUAL Dinning
• Half Shell Raw Bar Lands endMarina end ofMargaret St, sandwiches, fresh seafood, on the water
• BO’s Fish Wagon Carolyn andWilliam St small but very good and very casual
• Conch Republic Seafood Restaurant 631 Green St Causal open air on the docks
• Boathouse on the boardwalk under Commodores Restaurant, great happy hour and food.

Epistasis Discovery in Genetics and Epidemiology

The Epistasis Discovery in Genetics and Epidemiology (EDGE) conference focuses on the discussion and exploration of the impact of genetic interactions on complex traits and outcomes. The EDGE meeting yearly invites a varying group of experts in epistasis across multiple disciplines from animal models to biostatistics, providing a unique and synergistic environment for sharing ideas, identifying new topics of research, as well as the development of novel methodologies for understanding the impact of genetic interactions on complex traits and outcomes. As a result of EDGE, new manuscripts and algorithms have been developed and shared with the scientific community.

Publications as a result of meeting collaborations:

Van Steen K, Moore JH. How to increase our belief in discovered statistical interactions via large-scale association studies?  Hum Genet. 2019 Apr;138(4):293-305. doi: 10.1007/s00439-019-01987-w. PM 30840129, PMC 6483943

Full Article Available Here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483943/

Moore JH, Mackay TFC, Williams SM. Testing the assumptions of parametric linear models: the need for biological data mining in disciplines such as human genetics. BioData Min. 2019 Feb 11;12:6. doi: 10.1186/s13040-019-0194-z. PM 30792817, PMC 6371539 

Full Article Available Here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371539/

Ritchie MD, Van Steen K. The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation. Ann Transl Med. 2018 Apr;6(8):157. doi: 10.21037/atm.2018.04.05. PM 29862246, PMC 5952010  

Full Article Available Here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952010/

Ciesielski TH, Pendergrass SA, White MJ, Kodaman N, Sobota RS, Huang M, Bartlett J, Li J, Pan Q, Gui J, Selleck SB, Amos CI, Ritchie MD, Moore JH, Williams SM. Diverse convergent evidence in the genetic analysis of complex disease: coordinating omic, informatic, and experimental evidence to better identify and validate risk factors. BioData Min. 2014 Jun 30;7:10. doi: 10.1186/1756-0381-7-10. PM 29862246, PMC 4112852

Full Article Available Here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112852/

Mackay TF, Moore JH. Why epistasis is important for tackling complex human disease genetics. Genome Med. 2014 Jun 9;6(6):124. doi: 0.1186/gm561. PM 25031624, PMC 4062066  

Full Article Available Here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062066/

Hosts/Sponsors

Epistasis Discovery in Genetics and Epidemiology

The Epistasis Discovery in Genetics and Epidemiology (EDGE) conference focuses on the discussion and exploration of the impact of genetic interactions on complex traits and outcomes. The EDGE meeting yearly invites a varying group of experts in epistasis across multiple disciplines from animal models to biostatistics, providing a unique and synergistic environment for sharing ideas, identifying new topics of research, as well as the development of novel methodologies for understanding the impact of genetic interactions on complex traits and outcomes. As a result of EDGE, new manuscripts and algorithms have been developed and shared with the scientific community.

Publications as a result of meeting collaborations:

Van Steen K, Moore JH. How to increase our belief in discovered statistical interactions via large-scale association studies?  Hum Genet. 2019 Apr;138(4):293-305. doi: 10.1007/s00439-019-01987-w. PM 30840129, PMC 6483943

Full Article Available Here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483943/

Moore JH, Mackay TFC, Williams SM. Testing the assumptions of parametric linear models: the need for biological data mining in disciplines such as human genetics. BioData Min. 2019 Feb 11;12:6. doi: 10.1186/s13040-019-0194-z. PM 30792817, PMC 6371539 

Full Article Available Here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371539/

Ritchie MD, Van Steen K. The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation. Ann Transl Med. 2018 Apr;6(8):157. doi: 10.21037/atm.2018.04.05. PM 29862246, PMC 5952010  

Full Article Available Here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952010/

Ciesielski TH, Pendergrass SA, White MJ, Kodaman N, Sobota RS, Huang M, Bartlett J, Li J, Pan Q, Gui J, Selleck SB, Amos CI, Ritchie MD, Moore JH, Williams SM. Diverse convergent evidence in the genetic analysis of complex disease: coordinating omic, informatic, and experimental evidence to better identify and validate risk factors. BioData Min. 2014 Jun 30;7:10. doi: 10.1186/1756-0381-7-10. PM 29862246, PMC 4112852

Full Article Available Here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112852/

Mackay TF, Moore JH. Why epistasis is important for tackling complex human disease genetics. Genome Med. 2014 Jun 9;6(6):124. doi: 0.1186/gm561. PM 25031624, PMC 4062066  

Full Article Available Here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062066/

Hosts/Sponsors

5th Annual Epistasis Discovery in Genetics and Epidemiology (EDGE) Conference

Keynote Speakers:

Joan E. Bailey-Wilson, Ph.D.
Head, Statistical Genetics Section
Co-Branch Chief, Computational and Statistical Genomics Branch
National Human Genome Research Institute
National Institutes of Health

Alon Keinan, PhD
Associate Professor
Department of Biological Statistics & Computational Biology
Cornell University - Ithaca, NY

Trudy F. C. Mackay, PhD, FRS
William Neal Reynolds and Distinguished University Professor of Genetics
Director, Program in Genetics
Associate Director, Comparative Medicine Institute
Department of Biological Sciences
North Carolina State University

James Malley
Research Mathematical Statistician
Center for Information Technology
National Institutes of Health

Daniel R. Weinberger, M.D.
Director and CEO, Lieber Institute for Brain Development
Professor, Departments of Psychiatry, Neurology, Neuroscience and The Institute of Genetic Medicine
Johns Hopkins University School of Medicine

4th Annual Epistasis Discovery in Genetics and Epidemiology (EDGE) Conference

Registration is now closed. Please contact Suzy Unger with any questions.

Rooming Confirmations can be found here:

Marriott Key West Beachside Hotel
3841N. Roosevelt Blvd, Key West, FL(305) 296-8100

http://www.beachsidekeywest.com/index.php

Local Airport:

1. Key West International Airport is two miles east of Key West, in Monroe County, Florida. 
3. Address: 3491 S Roosevelt Blvd, Key West, FL 33040
4. Airport Code: EYW

..

Local Favorite Restaurants:

• Tavern and Town – Key West Marriott Beachside Resort –Key West’s premiere restaurant, delicious, imaginative dishes, perfect steaks and seafood.  Tapas specials on Tuesdays and Thursdays.
• Ambrosia Japanese Restaurant –1401 Simonton St. Outstanding sushi and innovative dishes served in their new home in the brand new Santa Maria Suites.  Lunch and Dinner daily.
• Mangia Mangia – 900 Southard – Mouthwatering pasta made fresh every day.  Nestled in an old town neighborhood.
• Michael’s – 532 Margaret –  famous for it’s steaks, but everything on the menu is wonderful.  The locals favorite steak house.
• Square One – 1075 Duval in Duval Square – Fine Dining Elegant American
• Alfonso  –700 Front St. – Beautiful harbor view, great steaks and seafood,Maine lobster.
• La Trattoria/Virgilio’s  524 Duval– Northern Italian, another local favorite with a great nightclub, Virgilio’s Martini Bar – that has music, dancing.
• Antonia’s 615 Duval St – Southern Italian Excellent homemade pasta and fine wines an excellent choice.
• El Meson De Pepe’s  410 Wall Street- Real Cuban- Conch Cuisine with Latin Music Nightly located just offMallory Square
• Grand Café 314 Duval St American Cuisine with Global Influences Fresh seafood and Steak
• Commodores white table cloths fine dinning excellent, one second floor on boardwalk
• Nine One Five 915 Duval St Tapas style dinning
• CASUAL Dinning
• Half Shell Raw Bar Lands endMarina end ofMargaret St, sandwiches, fresh seafood, on the water
• BO’s Fish Wagon Carolyn andWilliam St small but very good and very casual
• Conch Republic Seafood Restaurant 631 Green St Causal open air on the docks
• Boathouse on the boardwalk under Commodores Restaurant, great happy hour and food.

Keynote Speakers:

Dr. Trudy F. C. Mackay
Professor of Genetics and Associate Member of Entomology
North Carolina State University

Dr. Joan Bailey-Wilson
Head, Statistical Genetics Section
National Institutes of Health

Dr. Casey S. Greene
Assistant Professor, Department of Systems Pharmacology and Translational Therapeutics
Perelman School of Medicine, University of Pennsylvania

 Dr. Kevin Mitchell,
Developmental Neurogenetics, Smurfit Institute of Genetics,
University of Dublin,Trinity College,Dublin

Invited Guests:

Dr. James Malley
National Institutes of Health

EDGE 2016 Agenda:

   ** last updated 2/4/2016**

  Wednesday, February 3, 2016

  Arrivals

Thursday, February 4, 2016

**Note: Our meeting has moved to Salon C near the elevator**

Friday, February 5, 2016

 Saturday, February 6, 2016

 Departures

3rd Annual Epistasis Discovery in Genetics and Epidemiology (EDGE) Conference

EDGE Conference 2014

End Survey

Attendee List

Note Pad Pages

 February 5th -7th, 2014

Key West, Florida

Our Meeting is in Salon B. Head to the main building where you checked in, and take the stair case on your right when you walk into the building. We are on the second floor in the center meeting room. Look for Suzy at the Registration table! Meals are on the Terrace across from Salon B, and Cocktail Hours are Poolside!

Check the Rooming list for your confirmation number!

Keynote Speakers: Please fill out/sign this form and email it to Suzy! 

Hotel Shuttle Information:  If you call the hotel once you have arrived at the airport, have your bags and are ready to go. They will send a shuttle for you (it’s a very short drive)(305) 296-8100 is the hotel number. However, please keep in mind that the majority of our 32 attendees are arriving on Wednesday so there may be a wait for the hotel shuttle. There will be numerous taxi's available at the airport as well.

Agenda     :     Hotel Information     :     Local Resturants

Keynote Speakers:

AGENDA:  (printable version here)

Hotel Information:

 Marriott Key West Beachside Hotel

 http://www.beachsidekeywest.com/index.php

 3841 N. Roosevelt Blvd, Key West, FL

 (305) 296-8100 

 Rooming List is here: http://goo.gl/Twl2gn

Local Favorite Restaurants:

Tavern and Town – Key West Marriott Beachside Resort –Key West’s premiere restaurant, delicious, imaginative dishes, perfect steaks and seafood.  Tapas specials on Tuesdays and Thursdays.

Ambrosia Japanese Restaurant –1401 Simonton St. Outstanding sushi and innovative dishes served in their new home in the brand new Santa Maria Suites.  Lunch and Dinner daily.

Mangia Mangia – 900 Southard – Mouthwatering pasta made fresh every day.  Nestled in an old town neighborhood.

Michael’s – 532 Margaret –  famous for it’s steaks, but everything on the menu is wonderful.  The locals favorite steak house.

Square One – 1075 Duval in Duval Square – Fine Dining Elegant American

Alfonso  –700 Front St. – Beautiful harbor view, great steaks and seafood,Maine lobster.

La Trattoria/Virgilio’s  524 Duval– Northern Italian, another local favorite with a great nightclub, Virgilio’s Martini Bar – that has music, dancing.

Antonia’s 615 Duval St – Southern Italian Excellent homemade pasta and fine wines an excellent choice.

El Meson De Pepe’s  410 Wall Street- Real Cuban- Conch Cuisine with Latin Music Nightly located just offMallory Square

Grand Café 314 Duval St American Cuisine with Global Influences Fresh seafood and Steak

Commodores white table cloths fine dinning excellent, one second floor on boardwalk

Nine One Five 915 Duval St Tapas style dinning

CASUAL Dinning

Half Shell Raw Bar Lands endMarina end ofMargaret St, sandwiches, fresh seafood, on the water

BO’s Fish Wagon Carolyn andWilliam St small but very good and very casual

Conch Republic Seafood Restaurant 631 Green St Causal open air on the docks

Boathouse on the boardwalk under Commodores Restaurant, great happy hour and food.

EDGE conference

January 31st – February 1st, 2013

 Welcome to the first edition of the Epistasis Discovery in Genetic Epidemiology (EDGE) conference!  Below you will find the current Agenda, the hotel information and a listing of local restaurants.

We are in Salon B! Go to the main building (where you checked in) and up to the second floor.

Thanks for attending! Take the end survey here!

Agenda

Hotel Information

Local Resturants

Agenda:

Wednesday, January 30th

Arrival at the Marriott Key West Beachside Hotel (3841 N. Roosevelt Blvd)

Thursday, January 31st

7:00 am           Breakfast

8:00 am           30 Minute Presentations: (in no particular order)

Dr. Jason Moore

Dr. Chris Amos

Dr. Marylyn Ritchie

Ruowang Li – Ritchie Lab

Claire Reynolds – Selleck Lab

Ryan Urbanowicz – Moore Lab

Ting Hu – Moore Lab

12:00 pm        Lunch and Discussion

1:00 pm          Definition and refinement of questions for discussion

3:00 pm          Break

3:15 pm          Discussion

5:00 pm          Break

6:00 pm          Dinner Out

Friday, February 1st                                                                                 

7:00 am           Breakfast

8:00 am           Discussion of questions

10:00 am         Outline two papers to write in 2013

11:00 am         Discussion

12:00 pm        Lunch and Wrap up

1:00 pm          Free time

6:00 pm          Dinner out

Saturday, February 2nd

Departure

Hotel Information:

Marriott Key West Beachside Hotel

http://www.beachsidekeywest.com/index.php

3841 N. Roosevelt Blvd, Key West, FL

(305) 296-8100

** Please refer to the email that was sent previously for your confirmation number, If you cannot find this information, the front desk should be able to locate your reservation by name. **

Local Favorite Restaurants

Tavern and Town – Key West Marriott Beachside Resort –Key West’s premiere restaurant, delicious, imaginative dishes, perfect steaks and seafood.  Tapas specials on Tuesdays and Thursdays.

Ambrosia Japanese Restaurant –1401 Simonton St. Outstanding sushi and innovative dishes served in their new home in the brand new Santa Maria Suites.  Lunch and Dinner daily.

Mangia Mangia – 900 Southard – Mouthwatering pasta made fresh every day.  Nestled in an old town neighborhood.

Michael’s – 532 Margaret –  famous for it’s steaks, but everything on the menu is wonderful.  The locals favorite steak house.

Square One – 1075 Duval in Duval Square – Fine Dining Elegant American

Alfonso  –700 Front St. – Beautiful harbor view, great steaks and seafood,Maine lobster.

La Trattoria/Virgilio’s  524 Duval– Northern Italian, another local favorite with a great nightclub, Virgilio’s Martini Bar – that has music, dancing.

Antonia’s 615 Duval St – Southern Italian Excellent homemade pasta and fine wines an excellent choice.

El Meson De Pepe’s  410 Wall Street- Real Cuban- Conch Cuisine with Latin Music Nightly located just offMallory Square

Grand Café 314 Duval St American Cuisine with Global Influences Fresh seafood and Steak

Commodores white table cloths fine dinning excellent, one second floor on boardwalk

Nine One Five 915 Duval St Tapas style dinning

CASUAL Dinning

Half Shell Raw Bar Lands endMarina end ofMargaret St, sandwiches, fresh seafood, on the water

BO’s Fish Wagon Carolyn andWilliam St small but very good and very casual

Conch Republic Seafood Restaurant 631 Green St Causal open air on the docks

Boathouse on the boardwalk under Commodores Restaurant, great happy hour and food.