Biomedical and Translational Informatics Laboratory

Scott Dudek


Software Developer

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Current Projects

ATHENA – Platform for analyzing genetic data using evolutionary algorithms
PLATO – (PLatform for the Analysis, Translation, and Organization of large-scale data) incorporates a number of filters to select the important SNPs in a genome-wide association study.
Visualization – Developing tools for visualizing data and results for PheWAS projects


B.A. Biology
Washington University

Washington University School of Medicine

Work Experience

Software Developer
Ritchie Lab
Geisinger Health System

Software Developer
Ritchie Lab
Pennsylvania State University

Software Developer
Ritchie Lab
Vanderbilt University

Software Developer
Bioinformatics Core
Center for Human Genetics Research
Vanderbilt University


  • Bush W.S., Dudek S.M., Ritchie M.D. 2009. Biofilter: a knowledge-integration system for the multi-locus analysis of genome-wide association studies. Pacific Symposium on Biocomputing. 368-79.
  • Motsinger A.A., Fanelli T.J., Dudek S.M., Ritchie M.D. 2008. Balanced accuracy as a fitness function in grammatical evolution neural networks is robust to imbalanced data. GECCO. In press.
  • Edwards T.L., Lewis K.G., Velez D.R., Dudek S.M., Ritchie M.D. 2008. Exploring the Performance of Multifactor Dimensionality Reduction in Large Scale SNP Studies and in the Presence of Genetic Heterogeneity among Epistatic Disease Models. Human Heredity. 67(3):183-92.
  • Bush W.S., Edwards T.L., Dudek S.M., McKinney B.A., Ritchie M.D. 2008. Alternative contingency table measures improves the power and detection of Multifactor Dimensionality Reduction. BMC Bioinformatics. 9:238
  • Motsinger-Reif A.A., Dudek S.M., Hahn L.W., Ritchie M.D. 2008. Comparison of approaches for machine learning optimization of neural networks for detecting gene-gene interactions in genetic epidemiology. Genetic Epidemiology. 32(4):325-40.
  • Edwards T.L., Bush W.S., Turner S.D., Dudek S.M., Torstenson E.S., Schmidt M., Martin E., Ritchie M.D. 2008 Generating linkage disequilibrium patterns in data simulations using genomeSIMLA. Lecture Notes in Computer Science. 4973: 24-35.
  • Schwartz U.I., Ritchie M.D., Bradford Y., Dudek S., Frye-Anderson A., Kim R.B., Roden D.M., Stein C.M. 2008. Genetic determinants of response to warfarin during initial anticoagulation. NEJM. 358(10):999-1008. (PubMed)
  • Motsinger A.A., Reif D.M., Dudek S.M., Ritchie M.D. 2006. Dissecting the evolutionary process of grammatical evolution optimized neural networks. IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology. 1-8.
  • Bush W.S., Dudek S.M., Ritchie M.D. 2006. Parallel multifactor dimensionality reduction: a tool for the large-scale analysis of gene-gene interactions. Bioinformatics. 22:2173-4. (PubMed)
  • Motsinger A.A., Hahn L.W., Dudek S.M., Ryckman K.K., Ritchie M.D. 2006. Alternative Cross-Over Strategies and Selection Techniques for Grammatical Evolution Optimized Neural Networks. Proceedings of Genetic and Evolutionary Computation Conference. 947-949.
  • Motsinger A.A., Dudek S.M., Hahn L.W., Ritchie M.D. 2006. Comparison of Neural Network Optimization Approaches for Studies of Human Genetics. Lecture Notes in Computer Science. 3907:103-114.
  • Dudek SM, Motsinger AA, Velez DR, Williams SM, Ritchie MD. Data Simulation Software for Whole-Genome Association and Other Studies in Human Genetics. Pac Symp BioComput. 2006;:499-510.
  • Reif DM, Dudek SM, Shaffer CM, Wang J, Moore JH. Exploratory visual analysis of pharmacogenomic results. Pac Symp BioComput. 2005;:296-307.
  • Glossop NR, Houl JH, Zheng H, Ng FS, Dudek SM, Hardin PE. VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator. Neuron. 2003 Jan 23;37(2):249-61.
  • Bergelson J, Stahl E, Dudek S, Kreitman M. Genetic variation within and among populations of Arabidopsis thaliana. Genetics. 1998 Mar;148(3):1311-23. (PubMed)