Biomedical and Translational Informatics Laboratory

Yuki Bradford

yuki opt
 
 
 
 
Bioinformatics System Analyst (Geisinger Health System)

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Current Projects
eMERGE, GWAS analysis, Phewas analysis
 
Education
M.S. Statistics
University of Tennessee, Knoxville
 
M.S. Molecular Biology
Tennessee Technological University
 
B.S. Biology
Tennessee Technological University
 
Work Experience
 
Statistical Genetic Analyst
Computational Genomics Core / Center for Human Genetics Research
Vanderbilt University Medical Center
2007-2014
 
Biostatistician
Ritchie Lab / Center for Human Genetics Research

Vanderbilt University Medical Center

2003-2007
 
Statistician / Core Manager
Data Analysis Core / Center for Human Genetics Research
Vanderbilt University Medical Center
1999-2003
 
Population Data Analyst
BlueCross BlueShield of Tennessee
1997-1999
 
Quality Engineer Intern
Ocean Spray Cranberries
1996-1996
 
Publications
 
  • Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet. 2014 Aug;46(8):826-36. doi: 10.1038/ng.3014. Epub 2014 Jun 22. Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, Bradford Y, [......] Cappola TP, Olsen JV, Lage K, Schwartz PJ, Kääb S, Chakravarti A, Ackerman MJ, Pfeufer A, de Bakker PI, Newton-Cheh C.
  • KIAA1462, a coronary artery disease associated gene, is a candidate gene for late onset Alzheimer disease in APOE carriers. PLoS One 2013 12;8(12):e82194. Epub 2013 Dec 12. Deborah G Murdock, Yuki Bradford, Nathalie Schnetz-Boutaud, Ping Mayo, Melissa J Allen, Laura N D'Aoust, Xueying Liang, Sabrina L Mitchell, Stephan Zuchner, Gary W Small, John R Gilbert, Margaret A Pericak-Vance, Jonathan L Haines
  • Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenet Genomics 2013 Sep;23(9):470-8 Guillaume Pare, Michiaki Kubo, James B Byrd, Catherine A McCarty, Alencia Woodard-Grice, Koon K Teo, Sonia S Anand, Rebecca L Zuvich, Yuki Bradford, Stephanie Ross, Yusuke Nakamura, Marylyn Ritchie, Nancy J Brown
  • Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. Lancet . 2013 Aug 31;382(9894):790-6. doi: 10.1016/S0140-6736(13)60681-9. Epub 2013 Jun 5.Perera MA, Cavallari LH, Limdi NA, Gamazon ER, Konkashbaev A, Daneshjou R, Pluzhnikov A, Crawford DC, Wang J, Liu N, Tatonetti N, Bourgeois S, Takahashi H, Bradford Y , Burkley BM, Desnick RJ, Halperin JL, Khalifa SI, Langaee TY, Lubitz SA, Nutescu EA, Oetjens M, Shahin MH, Patel SR, Sagreiya H, Tector M, Weck KE, Rieder MJ, Scott SA, Wu AH, Burmester JK, Wadelius M, Deloukas P, Wagner MJ, Mushiroda T, Kubo M, Roden DM, Cox NJ, Altman RB, Klein TE, Nakamura Y, Johnson JA.
  • Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation. 2013 Apr 2;127(13):1377-85. doi: 10.1161/CIRCULATIONAHA.112.000604. Epub 2013 Mar 5. Ritchie MD, Denny JC, Zuvich RL, Crawford DC, Schildcrout JS, Bastarache L, Ramirez AH, Mosley JD, Pulley JM, Basford MA, Bradford Y, Rasmussen LV, Pathak J, Chute CG, Kullo IJ, McCarty CA, Chisholm RL, Kho AN, Carlson CS, Larson EB, Jarvik GP, Sotoodehnia N; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) QRS Group, Manolio TA, Li R, Masys DR, Haines JL, Roden DM.
  • Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality. Genetic epidemiology. 12/2011; 35(8):887-98. Rebecca L Zuvich, Loren L Armstrong, Suzette J Bielinski, Yuki Bradford, Christopher S Carlson, Dana C Crawford, Andrew T Crenshaw, Mariza de Andrade, Kimberly F Doheny, Jonathan L Haines [......] Andrew N McDavid, Daniel B Mirel, Lana M Olson, Justin E Paschall, Elizabeth W Pugh, Luke V Rasmussen, Laura J Rasmussen-Torvik, Stephen D Turner, Russell A Wilke, Marylyn D Ritchie
  • A Large Candidate Gene Survey Identifies the KCNE1 D85N Polymorphism as a Possible Modulator of Drug-Induced Torsades de Pointes. Cardiovascular genetics. 11/2011; 5(1):91-9. Stefan Kääb, Dana C Crawford, Moritz F Sinner, Elijah R Behr, Prince J Kannankeril, Arthur A M Wilde, Connie R Bezzina, Eric Schulze-Bahr, Pascale Guicheney, Nanette H Bishopric [......] Thomas Meitinger, Annette Peters, H-Erich Wichmann, Christiana Ingram, Yuki Bradford, Shannon Carter, Kris Norris, Marylyn D Ritchie, Alfred L George, Dan M Roden
  • Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. American journal of human genetics. 10/2011; 89(4):529-42. Joshua C Denny, Dana C Crawford, Marylyn D Ritchie, Suzette J Bielinski, Melissa A Basford, Yuki Bradford, High Seng Chai, Lisa Bastarache, Rebecca Zuvich, Peggy Peissig [......] Rongling Li, Teri A Manolio, Iftikhar J Kullo, Christopher G Chute, Rex L Chisholm, Eric B Larson, Catherine A McCarty, Daniel R Masys, Dan M Roden, Mariza de Andrade
  • Quality control procedures for genome-wide association studies. Current protocols in human genetics / editorial board01/2011; Chapter 1:Unit1.19. Stephen Turner, Loren L Armstrong, Yuki Bradford, Christopher S Carlson, Dana C Crawford, Andrew T Crenshaw, Mariza de Andrade, Kimberly F Doheny, Jonathan L Haines, Geoffrey Hayes [......] Martha Matsumoto, Catherine A McCarty, Andrew N McDavid, Daniel B Mirel, Justin E Paschall, Elizabeth W Pugh, Luke V Rasmussen, Russell A Wilke, Rebecca L Zuvich, Marylyn D Ritchie
  • Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. Genes and Immunity - GENES IMMUN , vol. 10, no. 7, pp. 624-630, 2009 J L McCauley, R L Zuvich, Y Bradford, S J Kenealy, N Schnetz-Boutaud, S G Gregory, S L Hauser, J R Oksenberg, D P Mortlock, M A Pericak-Vance, J L Haines
  • Genetic Determinants of Response to Warfarin During Initial Anticoagulation. Journal of Vascular Surgery.  J VASC SURG , vol. 47, no. 6, pp. 1372-1373, 2008 U. I. Schwartz, M. D. Ritchie, Y. Bradford
  • A Genome-wide Scan in an Amish Pedigree with Parkinsonism. Journal: Annals of Human Genetics - ANN HUM GENET , vol. 72, no. 5, pp. 621-629, 2008 S. L. Lee, D. G. Murdock, J. L. McCauley, Y. Bradford, A. Crunk, L. McFarland, L. Jiang, T. Wang, N. Schnetz-Boutaud, J. L. Haines
  • Genetic determinants of response to warfarin during initial anticoagulation. The New England journal of medicine. 04/2008; 358(10):999-1008.Ute I Schwarz, Marylyn D Ritchie, Yuki Bradford, Chun Li, Scott M Dudek, Amy Frye-Anderson, Richard B Kim, Dan M Roden, C Michael Stein
  • Familial mesial temporal lobe epilepsy maps to chromosome 4q13.2-q21.3. Neurology , vol. 68, no. 24, pp. 2107-2112, 2007 P. Hedera, M. A. Blair, E. Andermann, F. Andermann, D. D'Agostino, K. A. Taylor, L. Chahine, M. Pandolfo, Y. Bradford, J. L. Haines, B. Abou-Khalil
  • Identification of a novel locus for febrile seizures and epilepsy on chromosome 21q22. Epilepsia. 11/2006; 47(10):1622-8.Peter Hedera, Shaochun Ma, Marcia A Blair, Kelly A Taylor, Aline Hamati, Yuki Bradford, Bassel Abou-Khalil, Jonathan L Haines
  • Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44. Genes and Immunity - GENES IMMUN , vol. 7, no. 1, pp. 73-76, 2006 S J Kenealy, L A Herrel, Y Bradford, N Schnetz-Boutaud, J R Oksenberg, S L Hauser, L F Barcellos, S Schmidt, S G Gregory, M A Pericak-Vance, J L Haines
  • Familial essential tremor with apparent autosomal dominant inheritance: should we also consider other inheritance modes? Movement disorders : official journal of the Movement Disorder Society. 09/2006; 21(9):1368-74. Shaochun Ma, Thomas L Davis, Marcia A Blair, John Y Fang, Yuki Bradford, Jonathan L Haines, Peter Hedera
  • Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes. BMC medical genetics. 06/2004; 5:12. Holli B Hutcheson, Lana M Olson, Yuki Bradford, Susan E Folstein, Susan L Santangelo, James S Sutcliffe, Jonathan L Haines
  • A Second-Generation Genomic Screen for Multiple Sclerosis. American Journal of Human Genetics - AMER J HUM GENET , vol. 75, no. 6, pp. 1070-1078, 2004 S. J. Kenealy, M.-C. Babron, Y. Bradford, N. Schnetz-Boutaud, J. L. Haines, J. B. Rimmler, S. Schmidt, M. A. Pericak-Vance, L. F. Barcellos, R. R. Lincoln, J. R. Oksenberg, S. L. Hauser
  • Defining the autism minimum candidate gene region on chromosome 7. American Journal of Medical Genetics - AMER J 90-96, 2003 Holli B. Hutcheson, Y. Bradford, S. E. Folstein, M. B. Gardiner, S. L. Santangelo, J. S. Sutcliffe, J. L. Haines
  • Multiple susceptibility loci for multiple sclerosis. Human molecular genetics. 10/2002; 11(19):2251-6. Jonathan L Haines, Yuki Bradford, Melissa E Garcia, Allison D Reed, Elizabeth Neumeister, Margaret A Pericak-Vance, Jacqueline B Rimmler, Marissa M Menold, Eden R Martin, Jorge R Oksenberg, Lisa F Barcellos, Robin Lincoln, Stephen L Hauser
  • Incorporating language phenotypes strengthens evidence of linkage to autism American Journal of Medical Genetics. 08/2001; 105(6):539 - 547. Jonathan Haines, Yuki Bradford, Holli Hutcheson, Marybeth Gardiner, Terry Braun, Val Sheffield, Tom Cassavant, Wen Huang, Kai Wang, Veronica Vieland, Susan Folstein, Susan Santangelo, Joseph Piven
  • Linkage Disequilibrium at the Angelman Syndrome Gene UBE3A in Autism Families Genomics. 2001 Sep;77(1-2):105-13. Erika L. Nurmi, Yuki Bradford, Yi-hui Chen, Jenifer Hall, Brenda Arnone, Mary Beth Gardiner, Holli B. Hutcheson, John R. Gilbert, Margaret A. Pericak-Vance, Susan A. Copeland-Yates, Ron C. Michaelis, Thomas H. Wassink, Susan L. Santangelo, Val C. Sheffield, Joseph Piven, Susan E. Folstein, Jonathan L. Haines, James S. Sutcliffe